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    pgrn-1 Granulins domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgrn-1
    Official Full Name
    Granulins domain-containing protein
    Primary source
    WormBase:WBGene00011936
    Locus tag
    CELE_T22H2.6
    See related
    AllianceGenome:WB:WBGene00011936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular region. Is expressed in coelomocyte; intestine; neurons; and pseudocoelom. Used to study frontotemporal dementia. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgrn-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (11701852..11703698)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 4Fe-4S ferredoxin-type domain-containing protein Neighboring gene Serpentine Receptor, class I Neighboring gene G protein-coupled receptor Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Acyl_transf_3 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness. Wang AL, et al. Hum Mol Genet, 2024 Jan 20. PMID 37903062, Free PMC Article
    2. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects. Doyle JJ, et al. Proc Natl Acad Sci U S A, 2021 Jun 22. PMID 34140407, Free PMC Article
    3. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response. Hsu TY, et al. Methods Mol Biol, 2018. PMID 29956278
    4. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo Using Caenorhabditis elegans. Doyle JJ, et al. Methods Mol Biol, 2018. PMID 29956277
    5. The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels. Salazar DA, et al. J Neurosci, 2015 Jun 24. PMID 26109656, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
      Title: The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
    2. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
      Title: Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
    3. Cells that might otherwise recover from damage or injury are destroyed in progranulin mutants, which in turn facilitates disease progression.
      Title: A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Granulins domain-containing protein
    NP_492981.2
    • Confirmed by transcript evidence
    NP_492982.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11701852..11703698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060580.5 → NP_492981.2  Granulins domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9J5DXX3

    2. NM_060581.7 → NP_492982.2  Granulins domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9J5HVD3
    Nucleotide Protein
    Heading Accession and Version

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