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    rfth-1 Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 [ Caenorhabditis elegans ]

    Gene ID: 177216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rfth-1
    Official Full Name
    Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1
    Primary source
    WormBase:WBGene00022677
    Locus tag
    CELE_ZK180.3
    See related
    AllianceGenome:WB:WBGene00022677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process and glycolipid translocation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation In. Orthologous to human RFT1 (RFT1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rfth-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (4508496..4511309, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Gamma-aminobutyric acid type B receptor subunit 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Small COPII coat GTPase SAR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1
    NP_001023610.1
    • Confirmed by transcript evidence
    NP_001367982.1
    • Confirmed by transcript evidence
    NP_001368266.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4508496..4511309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028439.7 → NP_001023610.1  Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23444, Q86DD6, U4PBU5
      Conserved Domains (1) summary
      cl09326
      Location:2 → 511
      MATE_like; Multidrug and toxic compound extrusion family and similar proteins

    2. NM_001380194.1 → NP_001367982.1  Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl09326
      Location:1 → 365
      MATE_like; Multidrug and toxic compound extrusion family and similar proteins

    3. NM_001380195.1 → NP_001368266.1  Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl09326
      Location:1 → 134
      MATE_like; Multidrug and toxic compound extrusion family and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23444.1

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