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    F19C7.8 SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F19C7.8
    Official Full Name
    SH3 domain-containing protein
    Primary source
    WormBase:WBGene00017597
    Locus tag
    CELE_F19C7.8
    See related
    AllianceGenome:WB:WBGene00017597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in positive regulation of protein localization to plasma membrane and skeletal muscle contraction. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC (SH3 and cysteine rich domain); STAC2 (SH3 and cysteine rich domain 2); and STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F19C7.8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (4610575..4638095, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serine protease K12H4.7 Neighboring gene Secreted protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene pseudo Neighboring gene Vitelline membrane outer layer protein 1 Neighboring gene Serpentine Receptor, class T Neighboring gene Pheromone-regulated membrane protein 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_001294329.1
    • Confirmed by transcript evidence
    NP_001294330.1
    • Partially confirmed by transcript evidence
    NP_001368227.1
    • Confirmed by transcript evidence
    NP_741380.1
    • Partially confirmed by transcript evidence
    NP_741381.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4610575..4638095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307401.3 → NP_001294330.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLS7

    2. NM_171322.2 → NP_741380.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZT5

    3. NM_001307400.3 → NP_001294329.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBC2

    4. NM_171323.8 → NP_741381.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ71

    5. NM_001380202.1 → NP_001368227.1  SH3 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PAY0
    Nucleotide Protein
    Heading Accession and Version

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