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    sepa-1 Protein sepa-1 [ Caenorhabditis elegans ]

    Gene ID: 173196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sepa-1
    Official Full Name
    Protein sepa-1
    Primary source
    WormBase:WBGene00010808
    Locus tag
    CELE_M01E5.6
    See related
    AllianceGenome:WB:WBGene00010808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein-macromolecule adaptor activity. Involved in autophagy. Located in cytoplasm. Is expressed in head; intestine; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sepa-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (13298204..13300716, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NTF2 domain-containing protein Neighboring gene SKN-1 Dependent Zygotic transcript

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective autophagic degradation of maternally-loaded germline P granule components in somatic cells during C. elegans embryogenesis. Zhao Y, et al. Autophagy, 2009 Jul. PMID 19372764
    2. Detecting Autophagy in Caenorhabditis elegans Embryos Using Markers of P Granule Degradation. Palmisano NJ, et al. Cold Spring Harb Protoc, 2016 Jan 4. PMID 26729906, Free PMC Article
    3. Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes. Eckl J, et al. PLoS One, 2017. PMID 29078207, Free PMC Article
    4. CUP-5, the C. elegans ortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes. Sun T, et al. Autophagy, 2011 Nov. PMID 21997367
    5. The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation. Zhang G, et al. Autophagy, 2017 Sep 2. PMID 28806108, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein sepa-1
    NP_493339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13298204..13300716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060938.4 → NP_493339.1  Protein sepa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EC37
      Conserved Domains (1) summary
      pfam02172
      Location:600 → 676
      KIX; KIX domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EC37.1

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