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    ppgn-1 AAA+ ATPase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppgn-1
    Official Full Name
    AAA+ ATPase domain-containing protein
    Primary source
    WormBase:WBGene00021425
    Locus tag
    CELE_Y38F2AR.7
    See related
    AllianceGenome:WB:WBGene00021425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be located in membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ppgn-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (2333837..2348912, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nuclear receptor domain-containing protein Neighboring gene pseudo Neighboring gene Transcription Factor ThreeC subunit (GTF3C homolog) Neighboring gene Complex I assembly factor TIMMDC1, mitochondrial;Transmembrane protein;Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways. Chaudhari SN, et al. Nat Commun, 2017 Aug 3. PMID 28769038, Free PMC Article
    2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of m-AAA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AAA+ ATPase domain-containing protein
    NP_500191.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2333837..2348912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067790.8 → NP_500191.3  AAA+ ATPase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500191.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDB6
      Conserved Domains (2) summary
      TIGR01241
      Location:277 → 725
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam06480
      Location:111 → 212
      FtsH_ext; FtsH Extracellular
    Nucleotide Protein
    Heading Accession and Version

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