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    • Showing Current items.

    crn-7 Cell-death-related nuclease 7 [ Caenorhabditis elegans ]

    Gene ID: 176166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crn-7
    Official Full Name
    Cell-death-related nuclease 7
    Primary source
    WormBase:WBGene00007056
    Locus tag
    CELE_F09G8.2
    See related
    AllianceGenome:WB:WBGene00007056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Acts upstream of or within with a positive effect on negative regulation of antimicrobial peptide production. Is expressed in body wall musculature. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See crn-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (8268531..8270684)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein uS9m Neighboring gene Uncharacterized protein Neighboring gene MinK-related peptide, potassium channel accessory subunit protein 4 Neighboring gene Uncharacterized protein Neighboring gene C-type lectin domain-containing protein 160

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An arrhythmia susceptibility gene in Caenorhabditis elegans. Park KH, et al. J Biol Chem, 2007 Jul 6. PMID 17491013
    2. Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Yu H, et al. Biosci Rep, 2015 Apr 27. PMID 26182365, Free PMC Article
    3. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. Lai HJ, et al. PLoS One, 2009 Oct 7. PMID 19809494, Free PMC Article
    4. Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans. Yu H, et al. Biochem J, 2015 Aug 15. PMID 26251453
    5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRN-7 was found to play a role in degrading apoptotic DNA in distinct sites of the gonad.
      Title: Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease II activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cell-death-related nuclease 7
    NP_498817.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8268531..8270684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066416.4 → NP_498817.1  Cell-death-related nuclease 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498817.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34387, Q9NCF7
      Conserved Domains (3) summary
      cd09120
      Location:18 → 155
      PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
      cd09121
      Location:204 → 342
      PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
      pfam03265
      Location:21 → 340
      DNase_II; Deoxyribonuclease II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34387.2

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