npp-8 Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein;Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein;Nucleoporin_N domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npp-8
Official Full Name: Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein;Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein;Nucleoporin_N domain-containing protein
Primary source: WormBase:WBGene00003794
Locus tag: CELE_Y41D4B.19
See related: AllianceGenome:WB:WBGene00003794
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of nuclear pore. Involved in embryo development; nucleus organization; and regulation of exit from mitosis. Part of nuclear pore. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npp-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (1567921..1595824, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y41D4A_3073.a (e-PCR)
- UniSTS:322847

Y41D4A_3457.a (e-PCR)
- UniSTS:322850

STS4-106 (e-PCR)
- UniSTS:242093

Y41D4A_2768.a (e-PCR)
- UniSTS:324317

Y41D4A_3073.b (e-PCR)
- UniSTS:324318

Y41D4A_3457.d (e-PCR)
- UniSTS:324322

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore inner ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein;Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein;Nucleoporin_N domain-containing protein

NP_001294236.1

Confirmed by transcript evidence

NP_001343633.1

Confirmed by transcript evidence

NP_001359917.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1567921..1595824 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356908.4 → NP_001343633.1 Nucleoporin_N domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95Y15

Conserved Domains (1) summary

cl26447
Location:56 → 1208

Nucleoporin_N; Nup133 N terminal like
NM_001307307.3 → NP_001294236.1 Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294236.1

Status: REVIEWED

UniProtKB/TrEMBL

M1Z882

Conserved Domains (1) summary

COG5308
Location:4 → 244

NUP170; Nuclear pore complex subunit [Intracellular trafficking and secretion]
NM_001372721.2 → NP_001359917.1 Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95Y13

Conserved Domains (1) summary

pfam08801
Location:59 → 389

Nucleoporin_N; Nup133 N terminal like