hmg-1.2 High mobility group protein 1.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmg-1.2
Official Full Name: High mobility group protein 1.2
Primary source: WormBase:WBGene00001972
Locus tag: CELE_F47D12.4
See related: AllianceGenome:WB:WBGene00001972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; congestive heart failure; and syndromic microphthalmia 13. Orthologous to several human genes including HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hmg-1.2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (6280380..6282438)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HMG-1.2, together with chromatin-remodeling factors and calcium ions, is involved in the hypoxia response of hsp-16.1.
Title: Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F47D12.4 (e-PCR)
- UniSTS:318234

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: High mobility group protein 1.2

NP_001022599.1

Confirmed by transcript evidence

NP_001380090.1

Confirmed by transcript evidence

NP_001380091.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6280380..6282438

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392120.1 → NP_001380091.1 High mobility group protein 1.2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd01390
Location:133 → 198

HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
NM_001392119.1 → NP_001380090.1 High mobility group protein 1.2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O77096, Q09390

Conserved Domains (1) summary

cd01390
Location:135 → 200

HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
NM_001027428.6 → NP_001022599.1 High mobility group protein 1.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022599.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09390

Conserved Domains (1) summary

cd01390
Location:134 → 199

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...