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    zmp-3 Matrix metalloproteinase-C [ Caenorhabditis elegans ]

    Gene ID: 178748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zmp-3
    Official Full Name
    Matrix metalloproteinase-C
    Primary source
    WormBase:WBGene00016283
    Locus tag
    CELE_C31B8.8
    See related
    AllianceGenome:WB:WBGene00016283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables metallopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in anchor cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); obstructive lung disease (multiple); scleroderma (multiple); and tooth disease (multiple). Orthologous to several human genes including MMP1 (matrix metallopeptidase 1); MMP10 (matrix metallopeptidase 10); and MMP12 (matrix metallopeptidase 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zmp-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (2905767..2909625, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature Neighboring gene Seven TM Receptor Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Cloning, expression and immunologic identification of C31B8.8 gene of Caenorhabditis elegans]. Sun R, et al. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 2011 Aug. PMID 21972593
    2. CK2 Down-Regulation Increases the Expression of Senescence-Associated Secretory Phenotype Factors through NF-κB Activation. Song J, et al. Int J Mol Sci, 2021 Jan 2. PMID 33401686, Free PMC Article
    3. Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases. Wada K, et al. Gene, 1998 Apr 28. PMID 9573338
    4. Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs. Kelley LC, et al. Dev Cell, 2019 Feb 11. PMID 30686527, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Matrix metalloproteinase-C
    NP_503790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2905767..2909625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071389.6 → NP_503790.1  Matrix metalloproteinase-C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBU3
      Conserved Domains (3) summary
      cd00094
      Location:395 → 577
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:139 → 303
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam01471
      Location:55 → 117
      PG_binding_1; Putative peptidoglycan binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBU3.1

    Gene LinkOut

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