par-3 PDZ domain-containing protein;Partitioning defective protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: par-3
Official Full Name: PDZ domain-containing protein;Partitioning defective protein 3
Primary source: WormBase:WBGene00003918
Locus tag: CELE_F54E7.3
See related: AllianceGenome:WB:WBGene00003918
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol binding activity. Involved in several processes, including establishment of mitotic spindle orientation; gonad development; and polarity specification of anterior/posterior axis. Located in several cellular components, including P granule; anterior cell cortex; and apical cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including AB; EMS; excretory cell; hermaphrodite gonad; and vulval cell. Orthologous to several human genes including PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See par-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (5664233..5676795)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apical PAR protein caps orient the mitotic spindle in C. elegans early embryos.
Title: Apical PAR protein caps orient the mitotic spindle in C. elegans early embryos.
Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.
Title: Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.
Design principles for selective polarization of PAR proteins by cortical flows.
Title: Design principles for selective polarization of PAR proteins by cortical flows.
A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization.
Title: A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization.
Par-3 family proteins in cell polarity & adhesion.
Title: Par-3 family proteins in cell polarity & adhesion.
PAR-3 exists in a dynamic equilibrium between an unclustered form and a clustered form, in response to cortical tension mainly exerted by actomyosin contractility. Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.
Title: Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.
we find that vab-1 lies in the same genetic pathway as cdc-42 and is responsible for polarizing CDC-42 activity to the medial tip. Together, these data establish a previously uncharacterized role for polarized CDC-42, in conjunction with PAR-6, PAR-3 and an Eph receptor(vab-1), during epithelial intercalation.
Title: CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis.
PAR-3 and PAR-6 function in cytokinesis may be partially redundant and play a role in the maintenance of DYN-1 in the cleavage furrow.
Title: Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.
Centrosomes localize apically by first moving toward lateral foci of the conserved polarity proteins PAR-3 and PAR-6, then move together with these foci toward the future apical surface. Embryos lacking PAR-3 fail to localize their centrosomes apically.
Title: A role for the centrosome and PAR-3 in the hand-off of MTOC function during epithelial polarization.
a model of interactions between the Par proteins that includes both mutual inhibition and PAR-3 oligomerization
Title: PAR-3 oligomerization may provide an actin-independent mechanism to maintain distinct par protein domains in the early Caenorhabditis elegans embryo.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54E7.4 (e-PCR)
- UniSTS:322173

F54E7.3 (e-PCR)
- UniSTS:311787

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in anterior cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PDZ domain-containing protein;Partitioning defective protein 3

NP_001022607.1

Confirmed by transcript evidence

NP_001293664.1

Confirmed by transcript evidence

NP_001293665.1

Confirmed by transcript evidence

NP_001293668.1

Confirmed by transcript evidence

NP_001293669.1

Confirmed by transcript evidence

NP_001293670.1

Confirmed by transcript evidence

NP_001360234.1

Confirmed by transcript evidence

NP_001360237.1

Confirmed by transcript evidence

NP_001368258.1

Confirmed by transcript evidence

NP_001368259.1

Confirmed by transcript evidence

NP_001368260.1

Confirmed by transcript evidence

NP_001379567.1

Confirmed by transcript evidence

NP_001379568.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5664233..5676795

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027436.3 → NP_001022607.1 Partitioning defective protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022607.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17353, Q27GV0, Q95QE9

Conserved Domains (2) summary

cd00992
Location:513 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:68 → 216

DUF3534; Domain of unknown function (DUF3534)
NM_001392103.1 → NP_001379567.1 Partitioning defective protein 3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd00992
Location:513 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:69 → 150

DUF3534; N-terminal of Par3 and HAL proteins
NM_001306740.3 → NP_001293669.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293669.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRH0

Conserved Domains (2) summary

cd00992
Location:513 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:68 → 216

DUF3534; Domain of unknown function (DUF3534)
NM_001306739.3 → NP_001293668.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293668.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PM75

Conserved Domains (2) summary

cd00992
Location:513 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:68 → 216

DUF3534; Domain of unknown function (DUF3534)
NM_001306741.3 → NP_001293670.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293670.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PEM0

Conserved Domains (2) summary

cd00992
Location:513 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:68 → 216

DUF3534; Domain of unknown function (DUF3534)
NM_001379719.1 → NP_001368259.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBE6

Conserved Domains (2) summary

cd00992
Location:513 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:69 → 150

DUF3534; N-terminal of Par3 and HAL proteins
NM_001392104.1 → NP_001379568.1 Partitioning defective protein 3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd00992
Location:477 → 559

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:77 → 114

DUF3534; N-terminal of Par3 and HAL proteins
NM_001306735.2 → NP_001293664.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293664.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRG6

Conserved Domains (2) summary

cd00992
Location:434 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:65 → 137

DUF3534; Domain of unknown function (DUF3534)
NM_001306736.3 → NP_001293665.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293665.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PEL6

Conserved Domains (2) summary

cd00992
Location:434 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:65 → 137

DUF3534; Domain of unknown function (DUF3534)
NM_001372593.2 → NP_001360234.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBE2

Conserved Domains (2) summary

pfam07794
Location:816 → 983

DUF1633; Protein of unknown function (DUF1633)

cd00992
Location:434 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001372595.2 → NP_001360237.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBS3

Conserved Domains (1) summary

cd00992
Location:434 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001379721.1 → NP_001368258.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBR8

Conserved Domains (1) summary

cd00992
Location:434 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001379722.1 → NP_001368260.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PM79

Conserved Domains (1) summary

cd00992
Location:434 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...