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    fecl-1 FErroChelatase-Like [ Caenorhabditis elegans ]

    Gene ID: 172454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fecl-1
    Official Full Name
    FErroChelatase-Like
    Primary source
    WormBase:WBGene00010645
    Locus tag
    CELE_K07G5.6
    See related
    AllianceGenome:WB:WBGene00010645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ferrochelatase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fecl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (7149940..7151844, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TAFII28-like protein domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene CARMIL pleckstrin homology domain-containing protein Neighboring gene ncRNA Neighboring gene XPA C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ferrochelatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrochelatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FErroChelatase-Like
    NP_492023.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class fecl

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7149940..7151844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059622.8 → NP_492023.1  FErroChelatase-Like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBW5
      Conserved Domains (2) summary
      TIGR00109
      Location:26 → 313
      hemH; ferrochelatase
      cl02784
      Location:94 → 157
      Chelatase_Class_II; Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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