rap-1 Ras-related protein Rap-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rap-1
Official Full Name: Ras-related protein Rap-1
Primary source: WormBase:WBGene00004307
Locus tag: CELE_C27B7.8
See related: AllianceGenome:WB:WBGene00004307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in collagen and cuticulin-based cuticle development and epidermis development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including intestine; nervous system; rectal gland cell; reproductive system; and vulval precursor cell. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1A (RAP1A, member of RAS oncogene family) and RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rap-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (8916250..8918890, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.
Title: Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.
We conclude that RAP-1 is a positive regulator that promotes Ras-dependent inductive fate decisions. We hypothesize that PXF-1 activation of RAP-1 serves as a minor parallel input into the major LET-60/Ras signal through LIN-45/Raf
Title: Ras-Dependent Cell Fate Decisions Are Reinforced by the RAP-1 Small GTPase in Caenorhabditiselegans.
Data show that the RAP-1 and RAL-1/exocyst pathway act in parallel during larval stages, and suggest that the exocyst complex acts as a downstream RAL-1 effector in cell migration.
Title: RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
the pxf-1/rap pathway in C. elegans is required for maintenance of epithelial integrity, in which it probably functions in polarized secretion
Title: Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C27B7.8 (e-PCR)
- UniSTS:319072

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen and cuticulin-based cuticle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in collagen and cuticulin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ras-related protein Rap-1

NP_501549.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8916250..8918890 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069148.5 → NP_501549.1 Ras-related protein Rap-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501549.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18246

Conserved Domains (1) summary

cd04175
Location:3 → 166

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms