gsy-1 Glycogen [starch] synthase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gsy-1
Official Full Name: Glycogen [starch] synthase
Primary source: WormBase:WBGene00001793
Locus tag: CELE_Y46G5A.31
See related: AllianceGenome:WB:WBGene00001793
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Predicted to be involved in glycogen biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cardiovascular system disease and glycogen storage disease. Orthologous to human GYS1 (glycogen synthase 1) and GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gsy-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (12866446..12878121, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interaction of full-length GS-GN proteins is enhanced by an avidity effect imparted by a dimeric state of GN and a tetrameric state of GS.
Title: Structural basis for the recruitment of glycogen synthase by glycogenin.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y46G5.kk (e-PCR)
- UniSTS:323930

Y46G5.ll (e-PCR)
- UniSTS:324333

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glycogen [starch] synthase

NP_496736.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12866446..12878121 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064335.6 → NP_496736.1 Glycogen [starch] synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496736.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2D9

Conserved Domains (2) summary

cd03793
Location:43 → 636

GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...

pfam05693
Location:48 → 672

Glycogen_syn; Glycogen synthase