U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hrpr-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173086, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hrpr-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00002000
    Locus tag
    CELE_F58D5.1
    See related
    AllianceGenome:WB:WBGene00002000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Located in nucleus. Is expressed widely. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R) and SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hrpr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (12060271..12064897, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cystatin domain-containing protein Neighboring gene Kinase suppressor of Ras B Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene MARVEL domain-containing protein;Secreted protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A genetic screen identifies C. elegans eif-3.H and hrpr-1 as pro-apoptotic genes and potential activators of egl-1 expression. Jiang Y, et al. MicroPubl Biol, 2024. PMID 38434221, Free PMC Article
    2. HRP-2, the Caenorhabditis elegans homolog of mammalian heterogeneous nuclear ribonucleoproteins Q and R, is an alternative splicing factor that binds to UCUAUC splicing regulatory elements. Kabat JL, et al. J Biol Chem, 2009 Oct 16. PMID 19706616, Free PMC Article
    3. HRP-2, a heterogeneous nuclear ribonucleoprotein, is essential for embryogenesis and oogenesis in Caenorhabditis elegans. Kinnaird JH, et al. Exp Cell Res, 2004 Aug 15. PMID 15265690
    4. ALG-1 Influences Accurate mRNA Splicing Patterns in the Caenorhabditis elegans Intestine and Body Muscle Tissues by Modulating Splicing Factor Activities. Kotagama K, et al. Genetics, 2019 Jul. PMID 31073019, Free PMC Article
    5. Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. Zheleva A, et al. PLoS Genet, 2019 Sep. PMID 31525188, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HRP-2 is a protein responsible for regulating alternative splicing through binding interactions with the UCUAUC sequence
      Title: HRP-2, the Caenorhabditis elegans homolog of mammalian heterogeneous nuclear ribonucleoproteins Q and R, is an alternative splicing factor that binds to UCUAUC splicing regulatory elements.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RRM domain-containing protein
    NP_001129778.1
    • Confirmed by transcript evidence
    NP_493049.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12060271..12064897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060648.6 → NP_493049.2  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493049.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NLD1
      Conserved Domains (3) summary
      cd12249
      Location:199 → 277
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:280 → 362
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:376 → 445
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins

    2. NM_001136306.3 → NP_001129778.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3KYC2
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous