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    atln-1 GB1/RHD3-type G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177059, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atln-1
    Official Full Name
    GB1/RHD3-type G domain-containing protein
    Primary source
    WormBase:WBGene00021868
    Locus tag
    CELE_Y54G2A.2
    See related
    AllianceGenome:WB:WBGene00021868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D; hereditary sensory neuropathy type 1F; and hereditary spastic paraplegia 3A. Orthologous to several human genes including ATL3 (atlastin GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atln-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (2788689..2796813)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Gliding motility protein GldN;Lipoprotein Neighboring gene ncRNA Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites. Liu X, et al. Nat Commun, 2019 Feb 4. PMID 30718476, Free PMC Article
    2. Neurodegeneration-related genes influence C. elegans pharyngeal activity. Selvarathinam H, et al. MicroPubl Biol, 2024. PMID 38550607, Free PMC Article
    3. A conserved role for atlastin GTPases in regulating lipid droplet size. Klemm RW, et al. Cell Rep, 2013 May 30. PMID 23684613, Free PMC Article
    4. The E3 Ubiquitin Ligase SYVN1 Ubiquitinates Atlastins to Remodel the Endoplasmic Reticulum Network. Zhao Y, et al. iScience, 2020 Sep 25. PMID 32916628, Free PMC Article
    5. A membrane reticulum, the centriculum, affects centrosome size and function in Caenorhabditis elegans. Maheshwari R, et al. Curr Biol, 2023 Mar 13. PMID 36693370, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GB1/RHD3-type G domain-containing protein
    NP_001023492.1
    • Confirmed by transcript evidence
    NP_001023493.1
    • Confirmed by transcript evidence
    NP_001294252.1
    • Confirmed by transcript evidence
    NP_001294253.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2788689..2796813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028322.6 → NP_001023493.1  GB1/RHD3-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q688Z6
      Conserved Domains (2) summary
      pfam02841
      Location:351 → 447
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:43 → 325
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001028321.5 → NP_001023492.1  GB1/RHD3-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BMU4
      Conserved Domains (2) summary
      pfam02841
      Location:351 → 447
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:43 → 325
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001307323.3 → NP_001294252.1  GB1/RHD3-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLG5
      Conserved Domains (2) summary
      pfam02841
      Location:72 → 168
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:1 → 46
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001307324.3 → NP_001294253.1  GB1/RHD3-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PQS6
    Nucleotide Protein
    Heading Accession and Version

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