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    cash-1 Striatin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cash-1
    Official Full Name
    Striatin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00010631
    Locus tag
    CELE_K07C5.8
    See related
    AllianceGenome:WB:WBGene00010631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calmodulin binding activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of endocytic recycling; and regulation of Golgi organization. Predicted to be part of FAR/SIN/STRIPAK complex. Is expressed in hypodermis; intestine; nervous system; pharynx; and reproductive system. Orthologous to several human genes including STRN3 (striatin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cash-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (10362261..10365964)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Epoxide hydrolase 2 Neighboring gene putative tubulin polyglutamylase ttll-15 Neighboring gene Serpentine Receptor, class I Neighboring gene UDP-glucuronosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans. Martin SCT, et al. Mol Biol Cell, 2023 Aug 1. PMID 37314837, Free PMC Article
    2. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393
    3. STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo. Lu T, et al. Genetics, 2022 May 5. PMID 35298637, Free PMC Article
    4. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Pal S, et al. Curr Biol, 2017 Mar 20. PMID 28285997
    5. Conserved genes act as modifiers of invertebrate SMN loss of function defects. Dimitriadi M, et al. PLoS Genet, 2010 Oct 28. PMID 21124729, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Striatin N-terminal domain-containing protein
    NP_001360512.1
    • Confirmed by transcript evidence
    NP_505664.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10362261..10365964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073263.5 → NP_505664.2  Striatin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505664.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE12
      Conserved Domains (3) summary
      cd00200
      Location:354 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:364 → 411
      7WD40; WD40 repeat [structural motif]
      pfam08232
      Location:25 → 156
      Striatin; Striatin family

    2. NM_001373096.3 → NP_001360512.1  Striatin N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WY88
      Conserved Domains (3) summary
      cd00200
      Location:357 → 676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:367 → 414
      7WD40; WD40 repeat [structural motif]
      pfam08232
      Location:25 → 156
      Striatin; Striatin family
    Nucleotide Protein
    Heading Accession and Version

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