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    casy-1 Calsyntenin C-terminal domain-containing protein;Secreted calsyntenin-1 [ Caenorhabditis elegans ]

    Gene ID: 174006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    casy-1
    Official Full Name
    Calsyntenin C-terminal domain-containing protein;Secreted calsyntenin-1
    Primary source
    WormBase:WBGene00000403
    Locus tag
    CELE_B0034.3
    See related
    AllianceGenome:WB:WBGene00000403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including neuromuscular junction; neuronal cell body membrane; and synaptic cleft. Is expressed in gonadal sheath cell; intestine; and nervous system. Orthologous to several human genes including CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See casy-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (5945405..5956683, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Transposase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Glutamate Signaling in the Sensorimotor Circuit by CASY-1A/Calsyntenin in Caenorhabditis elegans. Thapliyal S, et al. Genetics, 2018 Apr. PMID 29475851, Free PMC Article
    2. The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction. Thapliyal S, et al. PLoS Genet, 2018 Mar. PMID 29529030, Free PMC Article
    3. CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans. Ikeda DD, et al. Proc Natl Acad Sci U S A, 2008 Apr 1. PMID 18381821, Free PMC Article
    4. A conserved function of C. elegans CASY-1 calsyntenin in associative learning. Hoerndli FJ, et al. PLoS One, 2009. PMID 19287492, Free PMC Article
    5. Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans. Kim B, et al. Elife, 2017 Sep 13. PMID 28901288, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate that CASY-1 is required to modulate the transport of GABAergic synaptic vesicle (SV) precursors through a possible interaction with the SV motor protein, UNC-104/KIF1A
      Title: The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction.
    2. experiments demonstrate a remarkable conservation of the molecular function of Calsyntenins between nematodes and humans and point at a role of C. elegans casy-1 in regulating a glutamate receptor signaling pathway
      Title: A conserved function of C. elegans CASY-1 calsyntenin in associative learning.
    3. learning is modulated by the released ectodomain of CASY-1
      Title: CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic vesicle transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic cleft IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calsyntenin C-terminal domain-containing protein;Secreted calsyntenin-1
    NP_001021110.1
    • Confirmed by transcript evidence
    NP_001040722.1
    • Confirmed by transcript evidence
    NP_001391112.1
    • Partially confirmed by transcript evidence
    NP_495189.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5945405..5956683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062788.7 → NP_495189.2  Secreted calsyntenin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495189.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KY57

    2. NM_001025939.7 → NP_001021110.1  Secreted calsyntenin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ED46, H2KY57, Q2L6X9
      Conserved Domains (3) summary
      cd11304
      Location:163 → 236
      Cadherin_repeat; Cadherin tandem repeat domain
      cl09101
      Location:70 → 140
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
      cl22861
      Location:398 → 512
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. NM_001404223.1 → NP_001391112.1  Calsyntenin C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QCC9

    4. NM_001047257.6 → NP_001040722.1  Secreted calsyntenin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2L6X9
    Nucleotide Protein
    Heading Accession and Version

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