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    rskn-2 Putative ribosomal protein S6 kinase alpha-2;Ribosomal protein S6 kinase [ Caenorhabditis elegans ]

    Gene ID: 172581, updated on 9-Dec-2024

    Summary

    Official Symbol
    rskn-2
    Official Full Name
    Putative ribosomal protein S6 kinase alpha-2;Ribosomal protein S6 kinase
    Primary source
    WormBase:WBGene00008311
    Locus tag
    CELE_C54G4.1
    See related
    AllianceGenome:WB:WBGene00008311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in TORC1 signaling and regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in body wall musculature; nervous system; non-striated muscle; and reproductive system. Orthologous to human RPS6KA4 (ribosomal protein S6 kinase A4) and RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rskn-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (8014406..8019581)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Bromo domain-containing protein Neighboring gene ncRNA Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene Nucleotide PPase Neighboring gene Cytochrome c domain-containing protein Neighboring gene RAP domain-containing protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Putative ribosomal protein S6 kinase alpha-2;Ribosomal protein S6 kinase
    NP_001040645.1
    • Confirmed by transcript evidence
    NP_001040646.1
    • Confirmed by transcript evidence
    NP_001348666.1
    • Confirmed by transcript evidence
    NP_001348667.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8014406..8019581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361776.4NP_001348667.1  Ribosomal protein S6 kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5ATM0
      Conserved Domains (3) summary
      smart00133
      Location:285344
      S_TK_X; Extension to Ser/Thr-type protein kinases
      cd14092
      Location:374685
      STKc_MSK_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase
      cl21453
      Location:22287
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001361775.4NP_001348666.1  Ribosomal protein S6 kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5ATN2
      Conserved Domains (3) summary
      smart00133
      Location:285344
      S_TK_X; Extension to Ser/Thr-type protein kinases
      cd14092
      Location:374694
      STKc_MSK_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase
      cl21453
      Location:22287
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001047180.5NP_001040645.1  Putative ribosomal protein S6 kinase alpha-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18846, Q1ZXU3
      Conserved Domains (4) summary
      smart00133
      Location:285344
      S_TK_X; Extension to Ser/Thr-type protein kinases
      smart00220
      Location:17284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14092
      Location:374693
      STKc_MSK_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase
      cl21453
      Location:22287
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001047181.3NP_001040646.1  Putative ribosomal protein S6 kinase alpha-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040646.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18846
      Conserved Domains (1) summary
      cl21453
      Location:1110
      PKc_like; Protein Kinases, catalytic domain