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    sqd-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqd-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00022235
    Locus tag
    CELE_Y73B6BL.6
    See related
    AllianceGenome:WB:WBGene00022235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3 and hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B) and HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqd-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (6324174..6326422)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Thioredoxin domain-containing protein Neighboring gene tRNA pseudouridine synthase Neighboring gene U6 snRNA-associated Sm-like protein LSm8 Neighboring gene Protein seu-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage. Scheckel C, et al. PLoS Genet, 2012 May. PMID 22693456, Free PMC Article
    2. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    3. Identification of proteins and miRNAs that specifically bind an mRNA in vivo. Theil K, et al. Nat Commun, 2019 Sep 16. PMID 31527589, Free PMC Article
    4. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article
    5. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001380079.1
    • Confirmed by transcript evidence
    NP_001380080.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6324174..6326422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392315.1 → NP_001380080.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4W5P0
      Conserved Domains (2) summary
      cd21608
      Location:30 → 104
      RRM2_NsCP33_like; RNA recognition motif 2 (RRM2) found in Nicotiana sylvestris chloroplastic 33 kDa ribonucleoprotein (NsCP33) and similar proteins
      cl17169
      Location:111 → 185
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001392316.1 → NP_001380079.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXR6
      Conserved Domains (2) summary
      cd21608
      Location:30 → 104
      RRM2_NsCP33_like; RNA recognition motif 2 (RRM2) found in Nicotiana sylvestris chloroplastic 33 kDa ribonucleoprotein (NsCP33) and similar proteins
      cl17169
      Location:111 → 185
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
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