gst-20 Glutathione S-transferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gst-20
Official Full Name: Glutathione S-transferase
Primary source: WormBase:WBGene00001768
Locus tag: CELE_Y48E1B.10
See related: AllianceGenome:WB:WBGene00001768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutathione transferase activity. Involved in determination of adult lifespan. Predicted to be located in cytoplasm. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gst-20 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003280.10 (13608154..13609824, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48E1B.10 (e-PCR)
- UniSTS:305933

F37B1.1 (e-PCR)
- UniSTS:316755

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Glutathione S-transferase

NP_496858.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13608154..13609824 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064457.4 → NP_496858.1 Glutathione S-transferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496858.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC71

Conserved Domains (3) summary

PTZ00057
Location:6 → 199

PTZ00057; glutathione s-transferase; Provisional

cd03192
Location:84 → 189

GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases

cd03039
Location:4 → 74

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...