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    spp-10 Saposin B-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spp-10
    Official Full Name
    Saposin B-type domain-containing protein
    Primary source
    WormBase:WBGene00004995
    Locus tag
    CELE_C28C12.7
    See related
    AllianceGenome:WB:WBGene00004995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Is expressed in body wall musculature; intestine; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; lung disease (multiple); respiratory syncytial virus infectious disease; sphingolipidosis (multiple); and toxic shock syndrome. Orthologous to several human genes including PSAP (prosaposin) and PSAPL1 (prosaposin like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spp-10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (8477180..8480656)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Helix-loop-helix protein hlh-12 Neighboring gene Saposin B-type domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans. Wabnig S, et al. PLoS One, 2015. PMID 26312752, Free PMC Article
    2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    3. Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. Baugh LR, et al. Genome Biol, 2005. PMID 15892873, Free PMC Article
    4. In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes. Venz R, et al. Geroscience, 2024 Apr. PMID 37644339, Free PMC Article
    5. The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. Baugh LR, et al. Development, 2005 Apr. PMID 15772128

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Saposin B-type domain-containing protein
    NP_741465.1
    • Confirmed by transcript evidence
    NP_741466.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8477180..8480656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171399.7 → NP_741465.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18276, Q18278
      Conserved Domains (2) summary
      smart00741
      Location:137 → 213
      SapB; Saposin (B) Domains
      pfam03489
      Location:181 → 213
      SapB_2; Saposin-like type B, region 2

    2. NM_171400.6 → NP_741466.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741466.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4JFH6
      Conserved Domains (3) summary
      smart00741
      Location:137 → 213
      SapB; Saposin (B) Domains
      pfam03489
      Location:181 → 213
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:139 → 174
      SapB_1; Saposin-like type B, region 1
    Nucleotide Protein
    Heading Accession and Version

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