pat-2 Integrin alpha pat-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pat-2
Official Full Name: Integrin alpha pat-2
Primary source: WormBase:WBGene00003929
Locus tag: CELE_F54F2.1
See related: AllianceGenome:WB:WBGene00003929
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables transmembrane signaling receptor activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and vulval cell fate specification. Located in M band; cell surface; and striated muscle dense body. Is expressed in body wall musculature; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; blood platelet disease (multiple); end stage renal disease; renal agenesis; and von Willebrand's disease 1. Orthologous to several human genes including ITGA2B (integrin subunit alpha 2b); ITGA5 (integrin subunit alpha 5); and ITGA8 (integrin subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pat-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (8818899..8825266)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, the cytoplasmic tails of alpha integrins can bypass signaling from members of the Rho family of GTPases during development.
Title: α integrin cytoplasmic tails can rescue the loss of Rho-family GTPase signaling in the C. elegans somatic gonad.
The formation of such halos depends on the integrins PAT-2/PAT-3, UNC-112 and the GEF protein UIG-1, but not on the canonical ced-1/6/7 or ced-2/5/12 signaling modules
Title: Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans.
Our data suggest that PAT-2 functions through UIG-1 for CDC-42 activation, which in turn leads to cytoskeletal rearrangement and apoptotic cell internalization by muscle cells.
Title: Integrin α PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans.
down-regulation of ina-1 is necessary for distal tip cell migration cessation and the up-regulation of pat-2 is required for directionality
Title: Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54F2.1 (e-PCR)
- UniSTS:311789

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vulval cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
part_of integrin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Integrin alpha pat-2

NP_498948.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8818899..8825266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066547.5 → NP_498948.1 Integrin alpha pat-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498948.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34446

Conserved Domains (3) summary

smart00191
Location:372 → 427

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1178 → 1192

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:473 → 920

Integrin_alpha2; Integrin alpha