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    ddl-3 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddl-3
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00013217
    Locus tag
    CELE_Y54G11A.8
    See related
    AllianceGenome:WB:WBGene00013217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Orthologous to human TTC19 (tetratricopeptide repeat domain 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddl-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (14340006..14344454, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transcriptional regulator;YTH domain-containing protein Neighboring gene FeS cluster biogenesis domain-containing protein Neighboring gene Protein lin-7 homolog Neighboring gene L51_S25_CI-B8 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_001022475.1
    • Confirmed by transcript evidence
    NP_001022476.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14340006..14344454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027304.4 → NP_001022475.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022475.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW00
      Conserved Domains (2) summary
      sd00006
      Location:126 → 162
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:132 → 209
      TPR_12; Tetratricopeptide repeat

    2. NM_001027305.6 → NP_001022476.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K742
      Conserved Domains (2) summary
      sd00006
      Location:125 → 161
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:131 → 208
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version

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