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    cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit [ Caenorhabditis elegans ]

    Gene ID: 180708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cst-1
    Official Full Name
    Serine/threonine-protein kinase cst-1 37kDa subunit
    Primary source
    WormBase:WBGene00017472
    Locus tag
    CELE_F14H12.4
    See related
    AllianceGenome:WB:WBGene00017472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in determination of adult lifespan and muscle cell development. Predicted to be active in cytoplasm. Is expressed in hypodermis; sensory neurons; terminal bulb; and vulva. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cst-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (4339632..4343706)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thrombospondin type 1 domain protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans. Feng G, et al. EMBO J, 2017 Feb 1. PMID 28011581, Free PMC Article
    2. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Iwasa H, et al. Exp Cell Res, 2013 Feb 1. PMID 23103556
    3. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Wilkinson DS, et al. Mol Cell, 2015 Jan 8. PMID 25544559, Free PMC Article
    4. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. Lee KK, et al. J Biol Chem, 2001 Jun 1. PMID 11278283
    5. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Iwasa H, et al. Exp Cell Res, 2013 Apr 15. PMID 23396260

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase cst-1 37kDa subunit
    NP_001024575.2
    • Confirmed by transcript evidence
    NP_508743.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4339632..4343706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029404.7 → NP_001024575.2  Serine/threonine-protein kinase cst-1 37kDa subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024575.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2AAC7, Q9NB31
      Conserved Domains (3) summary
      cd06612
      Location:31 → 286
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      smart00220
      Location:35 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam11629
      Location:446 → 493
      Mst1_SARAH; C terminal SARAH domain of Mst1

    2. NM_076342.6 → NP_508743.4  Serine/threonine-protein kinase cst-1 37kDa subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508743.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NB31
      Conserved Domains (3) summary
      cd06612
      Location:31 → 286
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      smart00220
      Location:35 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam11629
      Location:444 → 491
      Mst1_SARAH; C terminal SARAH domain of Mst1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NB31.1

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