egl-15 Myoblast growth factor receptor egl-15;receptor protein-tyrosine kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-15
Official Full Name: Myoblast growth factor receptor egl-15;receptor protein-tyrosine kinase
Primary source: WormBase:WBGene00001184
Locus tag: CELE_F58A3.2
See related: AllianceGenome:WB:WBGene00001184
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase activity. Involved in several processes, including egg-laying behavior; fibroblast growth factor receptor signaling pathway; and muscle cell cellular homeostasis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in head neurons; hypodermis; intestine; male sex myoblast; and vulval muscle. Used to study bone disease. Human ortholog(s) of this gene implicated in several diseases, including bone development disease (multiple); breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to several human genes including FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-15 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 24

Sequence:: Chromosome: X; NC_003284.9 (11016400..11023421)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor.
Title: The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor.
Egl-15 is required for neuromuscular junction regulation in response to stress. Egl-15 functions downstream of Skn-1 and sphk-1.
Title: A Receptor Tyrosine Kinase Network Regulates Neuromuscular Function in Response to Oxidative Stress in Caenorhabditis elegans.
Study identified the mechanism that maintains presynaptic distribution during postdevelopmental growth; the requirement of a SLC17 family transporter CIMA-1. CIMA-1 antagonizes a specific FGFR isoform, EGL-15(5A), in epidermal cells to modulate glial morphology, in turn modulating AIY synaptic distribution.[
Title: Synapse location during growth depends on glia location.
Intestinal tube formation in Caenorhabditis elegans requires egl-15 signaling
Title: Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling.
Results show that N-glycans negatively regulate EGL-15 FGFR activity in vivo supporting the notion that mutation of N-glycosylation sites in human FGFR may lead to inappropriate activation of the receptor.
Title: N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo.
EGL-15(5A) is predominantly expressed in the M lineage, which gives rise to the migrating sex myoblasts and their sex muscle descendants, while EGL-15(5B) is predominantly expressed in the hypodermis.
Title: Different isoforms of the C. elegans FGF receptor are required for attraction and repulsion of the migrating sex myoblasts.
EGL-15 and CLR-1 act in the hypodermis to regulate fluid homeostasis in worms
Title: FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans.
Reporters for egl-15 exons 5A and 5B showed tissue-specific profiles, and we isolated mutants defective in the tissue specificity.
Title: Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.
report the identification of a novel EGL-15 receptor isoform that is generated by alternate splicing; present evidence that the two different forms of EGL-15 are responsible for its two distinct functions
Title: Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58A3.2 (e-PCR)
- UniSTS:311920

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Myoblast growth factor receptor egl-15;receptor protein-tyrosine kinase

NP_001300355.1

Confirmed by transcript evidence

NP_001300356.1

Confirmed by transcript evidence

NP_001300364.1

Confirmed by transcript evidence

NP_001360406.1

Confirmed by transcript evidence

NP_001367004.1

Confirmed by transcript evidence

NP_001368579.1

Confirmed by transcript evidence

NP_001368580.1

Confirmed by transcript evidence

NP_001379182.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11016400..11023421

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313427.4 → NP_001300356.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVM0

Conserved Domains (5) summary

cd04974
Location:407 → 503

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

smart00410
Location:401 → 502

IG_like; Immunoglobulin like

pfam07714
Location:640 → 928

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:302 → 382

Ig; Immunoglobulin domain

cl21453
Location:627 → 933

PKc_like; Protein Kinases, catalytic domain
NM_001313426.3 → NP_001300355.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATB0

Conserved Domains (5) summary

cd04974
Location:407 → 503

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

smart00410
Location:401 → 502

IG_like; Immunoglobulin like

pfam07714
Location:640 → 928

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:302 → 382

Ig; Immunoglobulin domain

cl21453
Location:627 → 933

PKc_like; Protein Kinases, catalytic domain
NM_001373496.2 → NP_001360406.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AYK2

Conserved Domains (4) summary

smart00409
Location:41 → 126

IG; Immunoglobulin

cd04974
Location:407 → 503

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cl11960
Location:302 → 382

Ig; Immunoglobulin domain

cl21453
Location:627 → 933

PKc_like; Protein Kinases, catalytic domain
NM_001313435.5 → NP_001300364.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AYL0

Conserved Domains (6) summary

cd00096
Location:51 → 123

Ig; Immunoglobulin domain

cd04974
Location:355 → 451

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

smart00410
Location:349 → 450

IG_like; Immunoglobulin like

pfam07714
Location:588 → 876

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:250 → 330

Ig; Immunoglobulin domain

cl21453
Location:575 → 881

PKc_like; Protein Kinases, catalytic domain
NM_001392839.1 → NP_001379182.1 Myoblast growth factor receptor egl-15 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10656, Q7JL68, Q7YZM7, Q7YZM8, Q7YZN0, Q7YZN1, Q7Z025, Q8MQ14, Q93804, Q95QE0, Q95QE1

Conserved Domains (5) summary

smart00410
Location:41 → 126

IG_like; Immunoglobulin like

cd00096
Location:309 → 317

Ig; Ig strand B [structural motif]

cd04974
Location:392 → 501

IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:302 → 382

Ig; Immunoglobulin domain

cl21453
Location:627 → 933

PKc_like; Protein Kinases, catalytic domain
NM_001381095.1 → NP_001368580.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ASS4

Conserved Domains (5) summary

smart00410
Location:41 → 126

IG_like; Immunoglobulin like

cd00096
Location:257 → 265

Ig; Ig strand B [structural motif]

cd04974
Location:340 → 449

IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:250 → 330

Ig; Immunoglobulin domain

cl21453
Location:575 → 881

PKc_like; Protein Kinases, catalytic domain
NM_001381096.1 → NP_001368579.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATB5

Conserved Domains (5) summary

smart00410
Location:41 → 126

IG_like; Immunoglobulin like

cd00096
Location:257 → 265

Ig; Ig strand B [structural motif]

cd04974
Location:340 → 449

IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:250 → 330

Ig; Immunoglobulin domain

cl21453
Location:575 → 881

PKc_like; Protein Kinases, catalytic domain
NM_001381098.1 → NP_001367004.1 Myoblast growth factor receptor egl-15 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (5) summary

smart00410
Location:41 → 126

IG_like; Immunoglobulin like

cd00096
Location:257 → 265

Ig; Ig strand B [structural motif]

cd04974
Location:340 → 449

IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:250 → 330

Ig; Immunoglobulin domain

cl21453
Location:575 → 881

PKc_like; Protein Kinases, catalytic domain