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    pbrm-1 Bromo domain-containing protein;HMG box domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172504, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pbrm-1
    Official Full Name
    Bromo domain-containing protein;HMG box domain-containing protein
    Primary source
    WormBase:WBGene00007042
    Locus tag
    CELE_C26C6.1
    See related
    AllianceGenome:WB:WBGene00007042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity. Involved in gonad development. Predicted to be located in nucleus. Predicted to be part of RSC-type complex and SWI/SNF complex. Is expressed in several structures, including enteric muscle; hypodermis; nervous system; pharynx; and somatic cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pbrm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (7495437..7503582)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inverted formin-2;PUM-HD domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene SH3 domain-containing protein Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene GLOBIN domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14. Enríquez P, et al. J Biol Chem, 2021 Oct. PMID 34473995, Free PMC Article
    2. PBRM-1/PBAF-regulated genes in a multipotent progenitor in Caenorhabditis elegans. Mathies LD, et al. G3 (Bethesda), 2024 Mar 6. PMID 38150396, Free PMC Article
    3. Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development. Shibata Y, et al. Dev Biol, 2012 Jan 15. PMID 22119053
    4. The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans. Kuzmanov A, et al. Mol Cell Biol, 2014 Mar. PMID 24421384, Free PMC Article
    5. Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad. Large EE, et al. G3 (Bethesda), 2014 Mar 20. PMID 24402584, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PBRM-1/PBAF-regulated genes in a multipotent progenitor in Caenorhabditis elegans.
      Title: PBRM-1/PBAF-regulated genes in a multipotent progenitor in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bromo domain-containing protein;HMG box domain-containing protein
    NP_001021008.1
    • Confirmed by transcript evidence
    NP_001379442.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7495437..7503582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025837.4 → NP_001021008.1  Bromo domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEY5
      Conserved Domains (7) summary
      cd05515
      Location:710 → 815
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:343 → 443
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:40 → 153
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:822 → 936
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1451 → 1503
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1114
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cl02556
      Location:198 → 293
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    2. NM_001392571.1 → NP_001379442.1  HMG box domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q565A2
      Conserved Domains (2) summary
      cd00084
      Location:77 → 133
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam17017
      Location:161 → 238
      zf-C2H2_aberr; Aberrant zinc-finger
    Nucleotide Protein
    Heading Accession and Version

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