mom-5 Protein mom-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mom-5
Official Full Name: Protein mom-5
Primary source: WormBase:WBGene00003397
Locus tag: CELE_T23D8.1
See related: AllianceGenome:WB:WBGene00003397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including neuron migration; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to be located in early endosome and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anus; gonad; hypodermis; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; nonsyndromic congenital nail disorder 1; omodysplasia 2; and schizophrenia. Orthologous to several human genes including FZD1 (frizzled class receptor 1); FZD2 (frizzled class receptor 2); and FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mom-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (9965574..9970037)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Small GTPases mediate MOM-5's regulation of unc-5 such that one outcome of impaired function of small GTPases like CED-10/Rac and MIG-2/RhoG is an increase in unc-5 function.
Title: The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells.
Study shows that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control the anterior polarization of the mechanosensory neuron ALM.
Title: Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
In a Frizzled-dependent manner, PLR-1 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.
Title: The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
Rearrangement of mitotic spindles requires the MOM-5/Fz receptor. Apoptotic cell clearance and migration of the distal tip cell require the MOM-5/Fz receptor.
Title: The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division.
Title: C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division.
MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
Title: MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23D8.1 (e-PCR)
- UniSTS:315067

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in Wnt signaling pathway, regulating spindle positioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interneuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of distal tip cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Protein mom-5

NP_001300437.1

Confirmed by transcript evidence

NP_492635.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9965574..9970037

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060234.7 → NP_492635.1 Protein mom-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492635.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AWM6

Conserved Domains (2) summary

cd07458
Location:35 → 147

CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1

pfam01534
Location:218 → 548

Frizzled; Frizzled/Smoothened family membrane region
NM_001313508.3 → NP_001300437.1 Protein mom-5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AWM6, G5EEF7

Conserved Domains (2) summary

cd07458
Location:35 → 147

CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1

cd13951
Location:219 → 550

7tmF_Frizzled_SMO; class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor superfamily