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    rsp-2 putative splicing factor, arginine/serine-rich 2 [ Caenorhabditis elegans ]

    Gene ID: 174747, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rsp-2
    Official Full Name
    putative splicing factor, arginine/serine-rich 2
    Primary source
    WormBase:WBGene00004699
    Locus tag
    CELE_W02B12.2
    See related
    AllianceGenome:WB:WBGene00004699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including gonad development; nematode larval development; and regulation of growth rate. Located in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF5 (serine and arginine rich splicing factor 5) and SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rsp-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11451441..11452955, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein Neighboring gene putative splicing factor, arginine/serine-rich 1 Neighboring gene pseudo Neighboring gene Alanine--tRNA ligase, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SR protein RSP-2 influences expression of the truncated insulin receptor DAF-2B in Caenorhabditis elegans. Martinez BA, et al. G3 (Bethesda), 2023 Jun 1. PMID 36966398, Free PMC Article
    2. Transduplication resulted in the incorporation of two protein-coding sequences into the turmoil-1 transposable element of C. elegans. Sela N, et al. Biol Direct, 2008 Oct 8. PMID 18842128, Free PMC Article
    3. Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development. Kawano T, et al. Mech Dev, 2000 Jul. PMID 10906451
    4. Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons. Johns L, et al. Mol Cell Biol, 2007 Aug. PMID 17562857, Free PMC Article
    5. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SR protein RSP-2 influences expression of the truncated insulin receptor DAF-2B in Caenorhabditis elegans.
      Title: The SR protein RSP-2 influences expression of the truncated insulin receptor DAF-2B in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of growth rate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative splicing factor, arginine/serine-rich 2
    NP_496441.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11451441..11452955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064040.7 → NP_496441.1  putative splicing factor, arginine/serine-rich 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496441.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23120
      Conserved Domains (2) summary
      cd12337
      Location:3 → 71
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:112 → 184
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23120.1

    Gene LinkOut

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