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    enpp-1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179663, updated on 14-Nov-2024

    Summary

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    Official Symbol
    enpp-1
    Official Full Name
    Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein
    Primary source
    WormBase:WBGene00007753
    Locus tag
    CELE_C27A7.1
    See related
    AllianceGenome:WB:WBGene00007753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity. Predicted to be located in membrane. Predicted to be active in I band and striated muscle dense body. Is expressed in ciliated neurons; pharynx; and vas deferens cuboidal cell. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1); ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2); and ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See enpp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (12131457..12137395)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans. Nikonorova IA, et al. Curr Biol, 2022 May 9. PMID 35334227, Free PMC Article
    2. Cilia-Derived Extracellular Vesicles in Caenorhabditis Elegans: In Vivo Imaging and Quantification of Extracellular Vesicle Release and Capture. Razzauti A, et al. Methods Mol Biol, 2023. PMID 37140803
    3. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Wang L, et al. Protein Cell, 2016 Oct. PMID 27638466, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein
    NP_001041085.1
    • Confirmed by transcript evidence
    NP_001041086.1
    • Confirmed by transcript evidence
    NP_001129885.1
    • Confirmed by transcript evidence
    NP_001256405.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12131457..12137395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047620.4 → NP_001041085.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90754, Q2PJ70
      Conserved Domains (2) summary
      pfam01663
      Location:182 → 494
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:180 → 534
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. NM_001047621.3 → NP_001041086.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041086.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90754
      Conserved Domains (2) summary
      pfam01663
      Location:177 → 489
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:175 → 529
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. NM_001269476.3 → NP_001256405.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256405.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6U2
      Conserved Domains (2) summary
      pfam01663
      Location:168 → 480
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:166 → 520
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    4. NM_001136413.4 → NP_001129885.1  NUC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5BM33
      Conserved Domains (2) summary
      pfam01663
      Location:119 → 431
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:117 → 471
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90754.1

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