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    acl-2 1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [ Caenorhabditis elegans ]

    Gene ID: 179398, updated on 2-Nov-2024

    Summary

    Official Symbol
    acl-2
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
    Primary source
    WormBase:WBGene00011543
    Locus tag
    CELE_T06E8.1
    See related
    AllianceGenome:WB:WBGene00011543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) and AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See acl-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10028150..10031092, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Plant Late Embryo Abundant (LEA) related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
    NP_001256175.1
    • Confirmed by transcript evidence
    NP_001256176.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10028150..10031092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269246.5NP_001256175.1  Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22267
      Conserved Domains (2) summary
      cd07989
      Location:70250
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
      COG0204
      Location:62282
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    2. NM_001269247.3NP_001256176.1  1-acylglycerol-3-phosphate O-acyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HA82
      Conserved Domains (1) summary
      cd07989
      Location:1101
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like