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    prx-2 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178094, updated on 4-Jan-2025

    Summary

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    Official Symbol
    prx-2
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00004192
    Locus tag
    CELE_ZK809.7
    See related
    AllianceGenome:WB:WBGene00004192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in protein import into peroxisome matrix. Predicted to be located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See prx-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (11644129..11646322)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Splicing factor 45 Neighboring gene Transthyretin-like family protein Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Cardiac phospholamban Neighboring gene ncRNA Neighboring gene Tafazzin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans. Isermann K, et al. J Mol Biol, 2004 May 7. PMID 15099742
    2. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
    3. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
    4. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    5. Systematic analysis of genes required for synapse structure and function. Sieburth D, et al. Nature, 2005 Jul 28. PMID 16049479

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that peroxiredoxin 2 may protect two specific types of neurons from oxidative damage or, more likely, play a role in peroxide signaling in the nematode.
      Title: A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_502201.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11644129..11646322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069800.5 → NP_502201.2  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502201.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23601
      Conserved Domains (2) summary
      cd16526
      Location:215 → 253
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:17 → 188
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    Nucleotide Protein
    Heading Accession and Version

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