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    mgrn-1 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 181537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mgrn-1
    Official Full Name
    RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00007529
    Locus tag
    CELE_C11H1.3
    See related
    AllianceGenome:WB:WBGene00007529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of vulval development and protein localization to basolateral plasma membrane. Located in cytoplasmic vesicle. Is expressed in body wall musculature; nervous system; pharynx; and vulval precursor cell. Orthologous to human MGRN1 (mahogunin ring finger 1) and RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mgrn-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (14307863..14311683, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Golgi pH regulator Neighboring gene ncRNA Neighboring gene AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1 Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. Haag A, et al. PLoS Genet, 2014 May. PMID 24785082, Free PMC Article
    2. Detection of broadly expressed neuronal genes in C. elegans. Ruvinsky I, et al. Dev Biol, 2007 Feb 15. PMID 17046742
    3. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
    4. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, et al. Curr Biol, 2007 Feb 6. PMID 17276923
    5. An RNAi screen identifies genes that regulate GABA synapses. Vashlishan AB, et al. Neuron, 2008 May 8. PMID 18466746

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to basolateral plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin transferase
    NP_510385.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14307863..14311683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077984.7 → NP_510385.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17911
      Conserved Domains (3) summary
      COG5432
      Location:264 → 353
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16789
      Location:268 → 308
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      pfam16228
      Location:382 → 522
      DUF4887; Domain of unknown function (DUF4887)
    Nucleotide Protein
    Heading Accession and Version

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