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    him-18 SAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    him-18
    Official Full Name
    SAP domain-containing protein
    Primary source
    WormBase:WBGene00011415
    Locus tag
    CELE_T04A8.15
    See related
    AllianceGenome:WB:WBGene00011415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity and identical protein binding activity. Involved in DNA metabolic process; embryo development; and mitotic sister chromatid segregation. Located in nucleus. Part of Slx1-Slx4 complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group P. Orthologous to human SLX4 (SLX4 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See him-18 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (4712580..4715188, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Post-GPI attachment to proteins factor 2 Neighboring gene G-patch domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Suppressor of Ty 6 homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline. Saito TT, et al. PLoS Genet, 2012 Aug. PMID 22927825, Free PMC Article
    2. The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans. Hong Y, et al. PLoS Genet, 2018 Jun. PMID 29879106, Free PMC Article
    3. Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases. Agostinho A, et al. PLoS Genet, 2013. PMID 23901331, Free PMC Article
    4. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Smogorzewska A, et al. Mol Cell, 2010 Jul 9. PMID 20603073, Free PMC Article
    5. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. Saito TT, et al. PLoS Genet, 2013. PMID 23874210, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Slx1-Slx4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SAP domain-containing protein
    NP_497968.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4712580..4715188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065567.9 → NP_497968.3  SAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497968.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22145
    Nucleotide Protein
    Heading Accession and Version

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