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    aldo-2 Fructose-bisphosphate aldolase 2 [ Caenorhabditis elegans ]

    Gene ID: 175827, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aldo-2
    Official Full Name
    Fructose-bisphosphate aldolase 2
    Primary source
    WormBase:WBGene00017166
    Locus tag
    CELE_F01F1.12
    See related
    AllianceGenome:WB:WBGene00017166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to be located in cytoplasm and heterochromatin. Predicted to be active in cytosol. Is expressed widely. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See aldo-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (5874678..5876470, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF3456 domain-containing protein Neighboring gene PAP-associated domain-containing protein Neighboring gene MIF4G domain-containing protein Neighboring gene Abnormal cell migration protein 21 Neighboring gene ncRNA Neighboring gene COX assembly mitochondrial protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic enzymes aldo-2 and pdhb-1 as potential epigenetic regulators during C. elegans embryogenesis. Ravanelli S, et al. MicroPubl Biol, 2024. PMID 38947245, Free PMC Article
    2. The effects of plant cysteine proteinases on the nematode cuticle. Njom VS, et al. Parasit Vectors, 2021 Jun 5. PMID 34090505, Free PMC Article
    3. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
    4. Evidence of glutathione transferase complexing and signaling in the model nematode Caenorhabditis elegans using a pull-down proteomic assay. Greetham D, et al. Proteomics, 2004 Jul. PMID 15221760
    5. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-bisphosphate aldolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Fructose-bisphosphate aldolase 2
    NP_001021240.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5874678..5876470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026069.8 → NP_001021240.1  Fructose-bisphosphate aldolase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46563
      Conserved Domains (1) summary
      pfam00274
      Location:19 → 366
      Glycolytic; Fructose-bisphosphate aldolase class-I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46563.1

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