fust-1 RNA-binding protein FUS [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fust-1
Official Full Name: RNA-binding protein FUS
Primary source: WormBase:WBGene00016173
Locus tag: CELE_C27H5.3
See related: AllianceGenome:WB:WBGene00016173
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including gonad; head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in connective tissue cancer (multiple); essential tremor 4; and neurodegenerative disease (multiple). Orthologous to several human genes including FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fust-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (7152581..7155476)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fused in sarcoma regulates glutamate signaling and oxidative stress response.
Title: Fused in sarcoma regulates glutamate signaling and oxidative stress response.
An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans.
Title: An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans.
results suggest a role for FUS in regulating the activity of microRNA-mediated silencing.
Title: FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
Using a loss of function mutation, data show that fust-1 is a key gene acting to regulate neuronal integrity, lifespan and cellular stress responses. Also, for some of these functions, fust-1 is an active component of the insulin/IGF-like signaling pathway.
Title: FET proteins regulate lifespan and neuronal integrity.
ALS/FTD mutations in FUS induce phase transition into poorly soluble fibrillar hydrogels distinct from conventional amyloids. These assemblies are necessary and sufficient for neurotoxicity.
Title: ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C27H5.3 (e-PCR)
- UniSTS:312194

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding protein FUS

NP_001368629.1

Confirmed by transcript evidence

NP_495483.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7152581..7155476

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381492.1 → NP_001368629.1 RNA-binding protein FUS [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYQ6

Conserved Domains (2) summary

smart00547
Location:340 → 363

ZnF_RBZ; Zinc finger domain

cd12280
Location:145 → 226

RRM_FET; RNA recognition motif (RRM) found in the FET family of RNA-binding proteins
NM_063082.7 → NP_495483.1 RNA-binding protein FUS [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495483.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18265

Conserved Domains (3) summary

smart00547
Location:398 → 421

ZnF_RBZ; Zinc finger domain

COG0724
Location:202 → 290

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12280
Location:203 → 284

RRM_FET; RNA recognition motif in the FET family of RNA-binding proteins