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    fmo-2 Flavin-containing monooxygenase [ Caenorhabditis elegans ]

    Gene ID: 177958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fmo-2
    Official Full Name
    Flavin-containing monooxygenase
    Primary source
    WormBase:WBGene00001477
    Locus tag
    CELE_K08C7.5
    See related
    AllianceGenome:WB:WBGene00001477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables monooxygenase activity. Involved in defense response to Gram-negative bacterium and one-carbon metabolic process. Located in cytoplasm. Is expressed in excretory gland cell; head; intestine; and neurons. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO2 (flavin containing dimethylaniline monoxygenase 2); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fmo-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (10682524..10684367)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Laminin-like protein epi-1 Neighboring gene Uncharacterized protein Neighboring gene GLPGLI family protein Neighboring gene DUF4440 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C22 disrupts embryogenesis and extends C. elegans lifespan. Beydoun S, et al. Front Physiol, 2023. PMID 37791350, Free PMC Article
    2. Methodology to Metabolically Inactivate Bacteria for Caenorhabditis elegans Research. Beydoun S, et al. J Vis Exp, 2023 Jul 28. PMID 37578251, Free PMC Article
    3. Neurobiological Basis of Aversion-Resistant Ethanol Seeking in C. elegans. Jee C, et al. Metabolites, 2022 Dec 31. PMID 36676987, Free PMC Article
    4. NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection. Dasgupta M, et al. Infect Immun, 2020 Jul 21. PMID 32482643, Free PMC Article
    5. Genomic analysis of the telomeric length effect on organismic lifespan in Caenorhabditis elegans. Park MC, et al. Biochem Biophys Res Commun, 2010 May 28. PMID 20430011

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
      Title: NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
    2. Lifespan extension from knockdown of tald-1 is associated with an oxidative stress response involving p38 and c-Jun N-terminal kinase (JNK) MAPKs and a starvation-like response regulated by the transcription factor EB (TFEB) homolog HLH-30. The latter response promotes autophagy and increases expression of the flavin-containing monooxygenase 2 (fmo-2)
      Title: Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.
    3. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2).
      Title: Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Flavin-containing monooxygenase
    NP_501972.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10682524..10684367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069571.5 → NP_501972.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBJ9
      Conserved Domains (2) summary
      pfam00743
      Location:4 → 528
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:7 → 220
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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