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    gcy-3 Guanylate cyclase;Receptor-type guanylate cyclase gcy-3 [ Caenorhabditis elegans ]

    Gene ID: 191641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-3
    Official Full Name
    Guanylate cyclase;Receptor-type guanylate cyclase gcy-3
    Primary source
    WormBase:WBGene00001530
    Locus tag
    CELE_R134.1
    See related
    AllianceGenome:WB:WBGene00001530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ASER; ASIL; ASIR; and PVT. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (9502757..9507281, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Knot1 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Receptor-type guanylate cyclase gcy-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Yu S, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096403, Free PMC Article
    2. The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor. Baude EJ, et al. J Biol Chem, 1997 Jun 20. PMID 9188508
    3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
    4. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article
    5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Guanylate cyclase;Receptor-type guanylate cyclase gcy-3
    NP_001379015.1
    • Partially confirmed by transcript evidence
    NP_496037.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9502757..9507281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393157.1 → NP_001379015.1  Guanylate cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MMI8
      Conserved Domains (4) summary
      smart00044
      Location:859 → 1049
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06352
      Location:36 → 452
      PBP1_NPR_GC-like; ligand-binding domain of membrane guanylyl-cyclase receptors
      pfam07701
      Location:836 → 880
      HNOBA; Heme NO binding associated
      cl21453
      Location:552 → 821
      PKc_like; Protein Kinases, catalytic domain

    2. NM_063636.1 → NP_496037.1  Receptor-type guanylate cyclase gcy-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496037.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10028
      Conserved Domains (6) summary
      cd06352
      Location:36 → 453
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:861 → 1051
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:888 → 1076
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:54 → 433
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:839 → 882
      HNOBA; Heme NO binding associated
      cl21453
      Location:554 → 823
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10028.1

    Gene LinkOut

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