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    scd-2 ALK tyrosine kinase receptor homolog scd-2 [ Caenorhabditis elegans ]

    Gene ID: 179054, updated on 2-Nov-2024

    Summary

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    Official Symbol
    scd-2
    Official Full Name
    ALK tyrosine kinase receptor homolog scd-2
    Primary source
    WormBase:WBGene00004740
    Locus tag
    CELE_T10H9.2
    See related
    AllianceGenome:WB:WBGene00004740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in dauer larval development; sensory perception of chemical stimulus; and sensory processing. Predicted to be located in plasma membrane. Is expressed in body wall musculature; intestine; and nervous system. Orthologous to human ALK (ALK receptor tyrosine kinase) and LTK (leukocyte receptor tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See scd-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    22
    Sequence:
    Chromosome: V; NC_003283.11 (6633225..6639665)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene Palmitoyl-protein thioesterase 1 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene t-SNARE coiled-coil homology domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans. Wolfe GS, et al. eNeuro, 2019 Jul/Aug. PMID 31371455, Free PMC Article
    2. Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior of C. elegans. Boor SA, et al. Elife, 2024 Jan 17. PMID 38231572, Free PMC Article
    3. A neuropeptide signal confers ethanol state dependency during olfactory learning in Caenorhabditis elegans. Lindsay JH, et al. Proc Natl Acad Sci U S A, 2022 Nov 16. PMID 36343256, Free PMC Article
    4. Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans. Kitazono T, et al. J Neurosci, 2017 Oct 18. PMID 28924007, Free PMC Article
    5. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Hallberg B, et al. Nat Rev Cancer, 2013 Oct. PMID 24060861

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In C. elegans, after mapping and sequencing, lrn-2 was found to be allelic to the gene, scd-2. scd-2-mediated associative learning and sensory integration operate in separate neurons as separate processes.
      Title: A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans.
    2. SCD-2 and GCY-28 regulate sensory integration by modulating the activity of interneurons. Proper sensory integration is important for proper behavioral choices.
      Title: Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.
    3. SCD-2 encodes the nematode anaplastic lymphoma kinase (ALK) homolog, a proto-oncogene receptor tyrosine kinase.
      Title: C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of chemical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ALK tyrosine kinase receptor homolog scd-2
    NP_504685.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6633225..6639665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072284.4 → NP_504685.3  ALK tyrosine kinase receptor homolog scd-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504685.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76411
      Conserved Domains (4) summary
      smart00219
      Location:976 → 1241
      TyrKc; Tyrosine kinase, catalytic domain
      cd00112
      Location:305 → 338
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam12810
      Location:590 → 805
      Gly_rich; Glycine rich protein
      cl21453
      Location:969 → 1239
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76411.3

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