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    npr-20 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188226, updated on 4-Jan-2025

    Summary

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    Official Symbol
    npr-20
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00011578
    Locus tag
    CELE_T07D4.1
    See related
    AllianceGenome:WB:WBGene00011578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); hematologic cancer (multiple); and pyelonephritis (multiple). Orthologous to several human genes including CCR1 (C-C motif chemokine receptor 1); CCR10 (C-C motif chemokine receptor 10); and CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See npr-20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8860004..8865178, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Alanine--glyoxylate aminotransferase Neighboring gene Acyltransferase 3 domain-containing protein Neighboring gene V-SNARE coiled-coil homology domain-containing protein Neighboring gene UPF0046 protein T07D4.2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A database of Caenorhabditis elegans behavioral phenotypes. Yemini E, et al. Nat Methods, 2013 Sep. PMID 23852451, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_495888.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8860004..8865178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063487.5 → NP_495888.3  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495888.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFT1
      Conserved Domains (1) summary
      cd15012
      Location:32 → 365
      7tmA_Trissin_R; trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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