C23H4.6 AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C23H4.6
Official Full Name: AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein
Primary source: WormBase:WBGene00007694
Locus tag: CELE_C23H4.6
See related: AllianceGenome:WB:WBGene00007694
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be located in chromosome. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in several structures, including head mesodermal cell; nervous system; pharynx; rectal gland cell; and reproductive system. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See C23H4.6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (12235606..12240810)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C23H4.6 (e-PCR)
- UniSTS:321234

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein

NP_001257189.1

Confirmed by transcript evidence

NP_001257190.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12235606..12240810

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270260.4 → NP_001257189.1 RecF/RecN/SMC N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257189.1

Status: REVIEWED

UniProtKB/TrEMBL

P90750, Q93250

Conserved Domains (1) summary

COG1196
Location:70 → 1116

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001270261.4 → NP_001257190.1 AAA_23 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257190.1

Status: REVIEWED

UniProtKB/TrEMBL

B6VQ85

Conserved Domains (4) summary

PRK15354
Location:251 → 398

PRK15354; type III secretion system protein SsaK; Provisional

cd03276
Location:995 → 1086

ABC_SMC6_euk; ATP-binding cassette domain of eukaryotic SM6 proteins

COG1196
Location:20 → 1066

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl21455
Location:1 → 151

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases