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    nrd-1 CID domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrd-1
    Official Full Name
    CID domain-containing protein
    Primary source
    WormBase:WBGene00017004
    Locus tag
    CELE_D1007.7
    See related
    AllianceGenome:WB:WBGene00017004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Is expressed in several structures, including excretory cell; hypodermis; pharyngeal-intestinal valve; rectal gland cell; and reproductive system. Orthologous to several human genes including SCAF4 (SR-related CTD associated factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nrd-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (4597923..4602666, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 7TM_GPCR_Srx domain-containing protein;Gustatory receptor;PH domain-containing protein Neighboring gene Secreted protein Neighboring gene Ell-associated factor Eaf Neighboring gene Nucleic acid-binding, OB-fold protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
    2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CID domain-containing protein
    NP_491403.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4597923..4602666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059002.7 → NP_491403.1  CID domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491403.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01864
      Conserved Domains (5) summary
      smart00582
      Location:8 → 136
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      COG0724
      Location:524 → 597
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12227
      Location:523 → 599
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04554
      Location:740 → 787
      Extensin_2; Extensin-like region
      pfam06346
      Location:738 → 787
      Drf_FH1; Formin Homology Region 1
    Nucleotide Protein
    Heading Accession and Version

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