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    vps-22 Vacuolar-sorting protein SNF8 [ Caenorhabditis elegans ]

    Gene ID: 175672, updated on 2-Nov-2024

    Summary

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    Official Symbol
    vps-22
    Official Full Name
    Vacuolar-sorting protein SNF8
    Primary source
    WormBase:WBGene00016167
    Locus tag
    CELE_C27F2.5
    See related
    AllianceGenome:WB:WBGene00016167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT II complex. Is expressed in body wall musculature; intestine; neurons; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SNF8 (SNF8 subunit of ESCRT-II). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See vps-22 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (4960390..4961715, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene Methyltransferase BUD23 Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VPS-22/SNF8 regulates longevity via modulating the activity of DAF-16 in C. elegans. Han S, et al. Biochem Biophys Res Commun, 2020 Oct 29. PMID 32829877
    2. The ESCRT-II proteins are involved in shaping the sarcoplasmic reticulum in C. elegans. Lefebvre C, et al. J Cell Sci, 2016 Apr 1. PMID 26906413, Free PMC Article
    3. Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments. Fyfe I, et al. J Biol Chem, 2011 Sep 30. PMID 21835927, Free PMC Article
    4. The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation. Schuh AL, et al. Biochem J, 2015 Mar 15. PMID 25588614, Free PMC Article
    5. CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans. Roudier N, et al. Traffic, 2005 Aug. PMID 15998324

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT II complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar-sorting protein SNF8
    NP_498052.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4960390..4961715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065651.8 → NP_498052.1  Vacuolar-sorting protein SNF8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18258
      Conserved Domains (1) summary
      pfam04157
      Location:8 → 228
      EAP30; EAP30/Vps36 family
    Nucleotide Protein
    Heading Accession and Version

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