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    klo-2 Glycoside hydrolase family 1 protein [ Caenorhabditis elegans ]

    Gene ID: 184000, updated on 2-Nov-2024

    Summary

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    Official Symbol
    klo-2
    Official Full Name
    Glycoside hydrolase family 1 protein
    Primary source
    WormBase:WBGene00017103
    Locus tag
    CELE_E02H9.5
    See related
    AllianceGenome:WB:WBGene00017103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in hypodermis and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in congenital lactase deficiency; coronary artery disease; intracranial embolism; and spondylosis. Orthologous to several human genes including GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See klo-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (2446209..2448696)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Nuclear hormone receptor family member nhr-121 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans. Dueñas M, et al. Pharmacol Res, 2013 Oct. PMID 23856528
    2. The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans. Polanska UM, et al. J Biol Chem, 2011 Feb 18. PMID 21177529, Free PMC Article
    3. KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. Xu C, et al. EMBO Mol Med, 2017 Oct. PMID 28754744, Free PMC Article
    4. FGF23 signalling and physiology. Ho BB, et al. J Mol Endocrinol, 2021 Feb. PMID 33338030, Free PMC Article
    5. Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Château MT, et al. Aging (Albany NY), 2010 Sep. PMID 20844315, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings strongly indicate that a predicted KL1 isoform of Klotho requires the FGF signalling pathway to crosstalk with the Daf-2/insulin/Igf-like pathway, in order to regulate aging and oxidative stress resistance
      Title: Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glycoside hydrolase family 1 protein
    NP_001367723.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2446209..2448696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381778.1 → NP_001367723.1  Glycoside hydrolase family 1 protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZA0
      Conserved Domains (1) summary
      cl23725
      Location:7 → 467
      Glyco_hydro; Glycosyl hydrolases
    Nucleotide Protein
    Heading Accession and Version

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