atfs-1 Stress activated transcription factor atfs-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atfs-1
Official Full Name: Stress activated transcription factor atfs-1
Primary source: WormBase:WBGene00013878
Locus tag: CELE_ZC376.7
See related: AllianceGenome:WB:WBGene00013878
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atfs-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (14194446..14197697)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
Title: V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
The UPRmt preserves mitochondrial import to extend lifespan.
Title: The UPRmt preserves mitochondrial import to extend lifespan.
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
Title: Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
Title: FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
Title: LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
Title: Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Title: ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
While loss of atfs-1 during adulthood does not affect lifespan in any of these strains, absence of atfs-1 during development prevents clk-1 and isp-1 worms from reaching adulthood and reduces the lifespan of nuo-6 mutants.
Title: Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the mitochondrial unfolded protein response.
Title: Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
The bZip transcription factor ATFS-1 mediates mitochondrial stress-induced autophagy.
Title: Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC376.7 (e-PCR)
- UniSTS:308212

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitochondrial transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transcription	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Stress activated transcription factor atfs-1

NP_001024302.1

Confirmed by transcript evidence

NP_001256571.1

Confirmed by transcript evidence

NP_506515.1

Confirmed by transcript evidence

NP_872160.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14194446..14197697

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182360.9 → NP_872160.1 Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872160.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23272

Conserved Domains (1) summary

cd14692
Location:405 → 467

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
NM_074114.7 → NP_506515.1 Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506515.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E5QCH2, Q23272, Q52GY6, Q8I4B7

Conserved Domains (1) summary

cd14692
Location:421 → 483

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
NM_001029131.6 → NP_001024302.1 Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024302.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23272

Conserved Domains (1) summary

cd14692
Location:407 → 469

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
NM_001269642.3 → NP_001256571.1 Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256571.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23272

Conserved Domains (2) summary

cd09726
Location:136 → 277

RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

cd14692
Location:214 → 276

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain