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    mog-5 putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 [ Caenorhabditis elegans ]

    Gene ID: 173920, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mog-5
    Official Full Name
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5
    Primary source
    WormBase:WBGene00003393
    Locus tag
    CELE_EEED8.5
    See related
    AllianceGenome:WB:WBGene00003393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Involved in several processes, including embryonic body morphogenesis; feminization of hermaphroditic germ-line; and germ cell development. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX8 (DEAH-box helicase 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mog-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5399538..5405810)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase pink-1, mitochondrial Neighboring gene Putative RNA-binding protein EEED8.10 Neighboring gene C-type lectin domain-containing protein 141 Neighboring gene Putative RNA-binding protein EEED8.12 Neighboring gene Putative RNA-binding protein EEED8.4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spliceosomal helicases DDX41/SACY-1 and PRP22/MOG-5 both contribute to proofreading against proximal 3' splice site usage. Osterhoudt K, et al. RNA, 2024 Mar 18. PMID 38282418, Free PMC Article
    2. The Caenorhabditis elegans DDX-23, a homolog of yeast splicing factor PRP28, is required for the sperm-oocyte switch and differentiation of various cell types. Konishi T, et al. Dev Dyn, 2008 Sep. PMID 18729217
    3. The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22. Puoti A, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737793, Free PMC Article
    4. RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Seo M, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195740, Free PMC Article
    5. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in feminization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5
    NP_495019.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5399538..5405810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062618.7 → NP_495019.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495019.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09530
      Conserved Domains (6) summary
      smart00490
      Location:766 → 870
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:534 → 721
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:939 → 1021
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:557 → 695
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd05684
      Location:234 → 311
      S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
      pfam07717
      Location:1055 → 1154
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09530.1

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