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    tyr-5 Tyrosinase copper-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189907, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyr-5
    Official Full Name
    Tyrosinase copper-binding domain-containing protein
    Primary source
    WormBase:WBGene00021553
    Locus tag
    CELE_Y44E3B.2
    See related
    AllianceGenome:WB:WBGene00021553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to several human genes including TYR (tyrosinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tyr-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (3259797..3264283)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor zip-4 Neighboring gene Nop domain-containing protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    2. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosinase copper-binding domain-containing protein
    NP_491131.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3259797..3264283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058730.4 → NP_491131.2  Tyrosinase copper-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SR48, O76708
      Conserved Domains (1) summary
      pfam00264
      Location:149 → 338
      Tyrosinase; Common central domain of tyrosinase
    Nucleotide Protein
    Heading Accession and Version

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