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    pfkb-1.1 6-phosphofructo-2-kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172147, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pfkb-1.1
    Official Full Name
    6-phosphofructo-2-kinase domain-containing protein
    Primary source
    WormBase:WBGene00022456
    Locus tag
    CELE_Y110A7A.6
    See related
    AllianceGenome:WB:WBGene00022456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be active in cytosol. Orthologous to several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pfkb-1.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (5131520..5134105)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp31 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1 Neighboring gene Thymidylate synthase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328
    2. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article
    3. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase domain-containing protein
    NP_001379749.1
    • Confirmed by transcript evidence
    NP_491530.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5131520..5134105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392269.1 → NP_001379749.1  6-phosphofructo-2-kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N590
      Conserved Domains (2) summary
      pfam00300
      Location:249 → 435
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29 → 246
      6PF2K; 6-phosphofructo-2-kinase

    2. NM_059129.8 → NP_491530.1  6-phosphofructo-2-kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y85
      Conserved Domains (2) summary
      pfam01591
      Location:35 → 252
      6PF2K; 6-phosphofructo-2-kinase
      pfam00300
      Location:255 → 434
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
    Nucleotide Protein
    Heading Accession and Version

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