skpo-1 Peroxidase skpo-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: skpo-1
Official Full Name: Peroxidase skpo-1
Primary source: WormBase:WBGene00009897
Locus tag: CELE_F49E12.1
See related: AllianceGenome:WB:WBGene00009897
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables peroxidase activity. Involved in defense response to Gram-positive bacterium; determination of adult lifespan; and negative regulation of gene expression. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See skpo-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 16

Sequence:: Chromosome: II; NC_003280.10 (8400299..8404848, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis of Caenorhabditis elegans lacking heme peroxidase SKPO-1 reveals an altered response to Enterococcus faecalis.
Title: Transcriptome analysis of Caenorhabditis elegans lacking heme peroxidase SKPO-1 reveals an altered response to Enterococcus faecalis.
SKPO-1 functions protectively in the hypodermis during exposure to E. faecalis
Title: The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F49E12.1 (e-PCR)
- UniSTS:314402

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Peroxidase skpo-1

NP_495768.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8400299..8404848 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063367.8 → NP_495768.1 Peroxidase skpo-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495768.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20616

Conserved Domains (3) summary

cd09823
Location:275 → 619

peroxinectin_like; peroxinectin_like animal heme peroxidases

smart00254
Location:22 → 56

ShKT; ShK toxin domain

pfam03098
Location:143 → 623

An_peroxidase; Animal haem peroxidase