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    • Showing Current items.

    hil-3 Histone H1.3 [ Caenorhabditis elegans ]

    Gene ID: 181073, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hil-3
    Official Full Name
    Histone H1.3
    Primary source
    WormBase:WBGene00001854
    Locus tag
    CELE_F22F1.1
    See related
    AllianceGenome:WB:WBGene00001854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in several structures, including tail. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-8 (H1.8 linker histone). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hil-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_003284.9 (8159169..8160084)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene KIX domain-containing protein Neighboring gene CNDH2_C domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans. Jedrusik MA, et al. Development, 2001 Apr. PMID 11245572
    2. Inheritance of paternal DNA damage by histone-mediated repair restriction. Wang S, et al. Nature, 2023 Jan. PMID 36544019, Free PMC Article
    3. Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. Seydoux G, et al. Development, 1994 Oct. PMID 7607073
    4. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone H1.3
    NP_509375.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8159169..8160084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076974.6 → NP_509375.1  Histone H1.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19743
      Conserved Domains (1) summary
      pfam00538
      Location:38 → 111
      Linker_histone; linker histone H1 and H5 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19743.3

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