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    srb-6 Serpentine receptor class beta-6 [ Caenorhabditis elegans ]

    Gene ID: 191788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srb-6
    Official Full Name
    Serpentine receptor class beta-6
    Primary source
    WormBase:WBGene00005071
    Locus tag
    CELE_R05H5.6
    See related
    AllianceGenome:WB:WBGene00005071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane signaling receptor activity. Involved in defense response to Gram-positive bacterium and detection of chemical stimulus. Located in cilium. Is expressed in several structures, including chemosensory neurons; pharynx; phasmid neurons; tail; and uv1. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See srb-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (10194905..10196835)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene M-phase inducer phosphatase Neighboring gene WAP domain-containing protein Neighboring gene protein-disulfide reductase Neighboring gene Tyrosine-protein kinase Neighboring gene Protein ARV

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor. Tran A, et al. Elife, 2017 Sep 5. PMID 28873053, Free PMC Article
    2. The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression. Baran R, et al. Development, 1999 May. PMID 10207148
    3. A local interplay between diffusion and intraflagellar transport distributes TRPV-channel OCR-2 along C. elegans chemosensory cilia. van Krugten J, et al. Commun Biol, 2022 Jul 20. PMID 35858995, Free PMC Article
    4. HLH-14 is a C. elegans achaete-scute protein that promotes neurogenesis through asymmetric cell division. Frank CA, et al. Development, 2003 Dec. PMID 14627726
    5. The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans. Fujiwara M, et al. Genetics, 2015 Dec. PMID 26434723, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serpentine receptor class beta-6
    NP_496199.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10194905..10196835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063798.1 → NP_496199.1  Serpentine receptor class beta-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54141
      Conserved Domains (1) summary
      cl11607
      Location:12 → 244
      7TM_GPCR_Srab; Serpentine type 7TM GPCR receptor class ab chemoreceptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54141.1

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